Taiwanese researchers discover link between gene and rare brain disorder

MALFORMATION:
One of the causes of lissencephaly is mutation of the CEP85L gene, which might not be hereditary, a researcher said, urging prenatal controls

  • By Lee I-chia / Staff reporter

Researchers yesterday said that they have identified a gene that is an important cause for posterior predominant lissencephaly, a rare brain disorder.

Kaohsiung Chang Gung Memorial Hospital’s Department of Neurology Epilepsy Section director Tsai Meng-han (蔡孟翰) said that the brain normally has folds, or gyri, which correlate with specific cognitive abilities.

However, people with lissencephaly have gyral malformations that cause parts or the entire surface of their brains to appear smooth, which gives the disorder its name, meaning “smooth brain.”

Lissencephaly is a rare brain malformation caused by gene mutations, with an incidence rate of about 12 per million among newborns, he said, adding that there are an estimated 300 cases in Taiwan.

The life expectancy of most people

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Brain Mapping Foundation tackles COVID-19 pandemic through science, technology, innovation, and policy endorsing California Proposition 14-2020

Proposition 14-2020 provides $5.5B in total to continue stem cell research including $1.5B for the support of research and development of treatments toward neurological disorders.

LOS ANGELES, Sept. 16, 2020 /PRNewswire/ — Brain Mapping Foundation (BMF) and Society for Brain Mapping and Therapeutics (SBMT) have been on the forefront of combatting COVID-19 with their enormous network of scientists, physicians, and engineers worldwide.  BMF and SBMT formed a COVID-19 global taskforce in February of 2020 and by the first week of March they were connected to 5 different global taskforces in Asia, South America, North America, Middle East and India in real time. “Our taskforce coordinated efforts with our global membership and collaborators to rapidly advance our understanding of COVID-19,” said Vicky Yamamoto, Ph.D., Executive Director of SBMT, Co-Chair of COVID-19 Taskforce and Cancer Scientist, USC-Keck School of Medicine, Department of Otolaryngology/Head and Neck Surgery

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